2024 Lxr gene card

Lxr gene card

Author: zxnt

August undefined, 2024

WebApr 28, 2024 · LXR (liver X receptor) deficiency in myeloid cells accelerates the progression of atherosclerosis by increasing monocyte entry, foam cell formation, and plaque inflammation. Bulk cell-RNA profiling of plaque myeloid cells showed an upregulation of inflammatory mediators including oxidative, chemokine, and chemotactic genes. WebApr 1, 2024 · Liver X receptors (LXRs), LXR α and LXR β , are nuclear receptors that regulate the metabolism of cholesterol and bile acids and are activated by oxysterols. Humanized UGT1 ( hUGT1 ) mice express the 9-human UGT1A genes associated with the UGT1 locus in a Ugt1 -null background. The expression of UGT1A1 is developmentally …

Integrative analysis reveals multiple modes of LXR ... - PNAS

WebMar 19, 2015 · LXRs and LXR ligands have tissue-specific functions and mechanisms, and the heterogeneity of the different types of cancers and the emerging mechanistic … WebNov 8, 2013 · Direct LXR target genes include those encoding the ATP-binding cassette (ABC) transporter A1 (ABCA1) and the ABC transporter G1 (ABCG1), which govern cholesterol efflux from macrophages and peripheral organs, and the inducible degrader of LDL receptor ( Idol [also known as Mylip ]), which decreases LDL receptor protein levels … lake santa

Targeting liver X receptors in cancer therapeutics - Nature

WebLXR-RXR complex is linked to the responsive element LXR (LXRE) in DNA, a region of direct repetition 4 (DR4), recognized as the consensus sequence (5′-AGGTCA-NNNN-AGGTCA-3′) ( Willy et al., 1995 ). At baseline, LXR-RXR complex is associated with co-repressors (complexes containing NCoR or SMRT) that suppress genetic expression. WebHow to solve problems with LXR files. Associate the LXR file extension with the correct application. On : Windows: Right click on any LXR file and then click "Open with" > … WebNational Center for Biotechnology Information jenis jenis katrol

Liver X Receptor Alpha - an overview ScienceDirect …

National Center for Biotechnology Information

The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. Additionally, they play an important role in the local activation of thyroid hormones via deiodinases. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ i… WebLiver X receptor (LXR) α and LXRβ (encoded by Nr1h3 and Nr1h2) play important roles in hepatic lipid metabolism. LXRs are crucial for the lipogenic response to feeding as … lake santa barbaraWebThe glucocorticoid receptor (GR) is a crucial target gene for glucocorticoid-induced insulin resistance and hepatic gluconeogenesis linked to the development of type 2 diabetes. The liver X receptors (LXRs) are nuclear receptors that play an important role in the regulation of the metabolic gene linked to carbohydrate homeostasis. lake santa clara hoa

"WebFind many great new & used options and get the best deals for 1970 Topps #29 Gene Washington Minnesota Vikings at the best online prices at eBay! Free shipping for many products! ... Gene Washington signed 1970 Topps Rookie card #29-Minnesota Vikings (CHOF) $29.99 + $4.50 shipping. 1970 GENE WASHINGTON - Topps Football Card- # … " - Lxr gene card

Lxr gene card

National Center for Biotechnology Information

WebLiver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2). [5] WebLiver X Receptor. LXR is a sterol sensor that promotes lipogenesis, whereas PPARα controls a variety of genes in several pathways of lipid metabolism. ... Scd1 is eliminated …

Did you know?

WebJun 14, 2024 · LXRs bind to and regulate the expression of genes that encode proteins involved in cholesterol absorption, transport, efflux, excretion and conversion to bile … WebLXR-RXR complex is linked to the responsive element LXR (LXRE) in DNA, a region of direct repetition 4 (DR4), recognized as the consensus sequence (5′-AGGTCA-NNNN …

WebFeb 1, 2004 · The nuclear receptors liver X receptor (LXR)α and LXRβ are sensors of cholesterol metabolism and lipid biosynthesis. They have recently been found to be … WebGene Aliases COSMIC IDs SNP IDs Nucleotide Mutations (e.g. c.2582T>A) Amino Acid Changes (e.g. p.L861Q) RefSeq Accessions. Supported Keywords: Gene symbol Assay ID Plate SKU. Supported Keywords: miRBase ID Assay ID Plate SKU. Supported Keywords: Gene Name Gene ID Assay ID. Supported Keywords: sgRNA IDs Entrez Gene IDs …

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands they were subsequently deorphanized. WebFeb 2, 2024 · The nuclear receptors liver X receptor (LXR) α and β play crucial roles in hepatic metabolism. Many genes induced in response to pharmacologic LXR agonism have been defined; however, the transcriptional consequences of loss of LXR binding to its genomic targets are less well characterized.

WebJan 17, 2012 · The LXR/RXR is a so-called permissive heterodimer; in that it can be activated by ligands for either LXR or RXR. The heterodimer binding to LXR-responsive elements (LXREs) in DNA consists of direct repeats (DRs) of the core sequence AGGTCA separated by 4 nucleotides (DR-4).

Web1973 TOPPS VINTAGE CARD SIGNED AUTO GENE WASHINGTON MINNESOTA VIKINGS GREAT. $7.99 + $3.50 shipping. 1973 TOPPS GENE WASHINGTON MINNESOTA VIKINGS #359. $4.00. Free shipping. 1973 TOPPS GENE WASHINGTON MINNESOTA VIKINGS #359. $4.00. Free shipping. Picture Information. Picture 1 of 1. … jenis jenis kata serapanWebLXRs bind to the promoters of specific target genes as heterodimers with the retinoid X receptor (RXR; NR2B1). The sequence elements identified by the LXRs are direct repeat … lake san pedro campingWebLiver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity Expression of some LXR-dependent genes is related to breast tumor … lake santa barbara floridaWebNational Center for Biotechnology Information jenis jenis kawat las smawWebMar 21, 2024 · Tocris Summary for NR1H2 Gene. Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated nuclear receptor … FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with … AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, … PPARGC1A (PPARG Coactivator 1 Alpha) is a Protein Coding gene. Diseases … NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) is a Protein Coding … KMT2C (Lysine Methyltransferase 2C) is a Protein Coding gene. Diseases … APOE (Apolipoprotein E) is a Protein Coding gene. Diseases associated with … CEBPB (CCAAT Enhancer Binding Protein Beta) is a Protein Coding gene. … ABCB1 (ATP Binding Cassette Subfamily B Member 1) is a Protein Coding gene. … NFKB1 (Nuclear Factor Kappa B Subunit 1) is a Protein Coding gene. Diseases … AKT2 (AKT Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases … lake santa barbara pompanoWebFeb 1, 2024 · In contrast, a single LXR-like sequence was identified in the genome and transcriptome datasets of the Japanese lamprey, Lethenteron japonicum. Searches to the genome assembly and transcriptomes of the sea lamprey, Petromyzon marinus, allowed also the identification of a single LXR-like gene although too short for phylogenetic … lake san marcos stand up paddle boardWebOct 1, 2009 · Liver X receptor-alpha (LXR-α), being a member of the nuclear receptor/transcription factor family, has been widely recognized to have a pleiotropic effect in the regulation of genes involved in ... jenis jenis kawat las