WebPARP inhibitors (PARPi) have shown have activity in the treatment of ovarian cancer. Previous studies documented activity in patients with germline (gBRCA) and tumor … Web14 Apr 2024 · PARP-Targeting PET Tracer to Guide DDR Inhibitor Therapy. Pantel et al. Page 1515. ... FTT) to predict ovarian cancer response to PARP inhibitors (PARPi) alone and in combination with ATR inhibition. This study builds on earlier work demonstrating the ability of [18F]FTT to quantify regional PARPi binding and by testing the ability of [18F]FTT ...
PARP Inhibitors: Where Are We in 2024 and What’s …
Webpoints, and responses to platinum and PARP inhibition (PARPi) therapy. In particular, a treatment-naive PDX with homologous recombination deficiency (HRD) was sensitive to … Web14 Apr 2024 · Summary. Functional PET imaging using a PARP inhibitor (PARPi) analog may serve as an early, dynamic biomarker of response to PARPi therapy in high-grade serous ovarian cancer. Clinically, this could help to rapidly identify PARPi nonresponders, thereby maximizing efficacy and avoiding toxicities of futile treatments.See related article by … snowminds
Frontiers PARP Inhibitors: Clinical Relevance, Mechanisms of …
Web14 Apr 2024 · Introduction. Castration-resistant prostate cancer (CRPC), particularly metastatic castration-resistant prostate cancer (mCRPC) is one of the most common cancers in males and affects millions of men worldwide with high morbidity and mortality (Siegel et al., 2024).Treatments for mCRPC are various including chemotherapy, … Web28 Dec 2024 · Inhibitors of poly (ADP-ribose) polymerase (PARPi) have entered the clinic for the treatment of patients with cancers that lack homology-directed DNA repair, but drug … WebAlso, the appropriate time to switch therapy to PARPi is unclear. In the POLO trial , one-third of patients received platinum-based therapy for more than 6 months. On subgroup analysis for PFS, patients who received platinum-based therapy for >6 months seemed to have a greater benefit (HR 0.35, 95% CI 0.17–0.72) as compared to 4–6 months ... snowmetrics